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Nuedexta mainly prescribed for dementia, Parkinson’s
- Author:
- Amy Karon
Only 15.2% of patients had multiple sclerosis or amyotrophic lateral sclerosis, the diagnoses of patients in the studies leading to the approval...
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Pyrotinib shows promise in HER2-mutant non–small cell lung cancer
- Author:
- Amy Karon
In a phase 2 trial of 15 adults with progressive HER2-mutant NSCLC, objective response rate was 53%, median overall survival was 12.9 months, and...
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Childhood inflammatory bowel disease linked to increased mortality
- Author:
- Amy Karon
The risk of death was three- to fivefold higher than that in the general population.
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Metachronous advanced neoplasia linked to diminutive polyp number, not histology
- Author:
- Amy Karon
Metachronous advanced neoplasia was diagnosed in similar proportions of patients with and without high-risk diminutive polyps.
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Studies support vedolizumab-calcineurin inhibitor combinations but not accelerated infliximab therapy for refractory UC
- Author:
- Amy Karon
Rates of colectomy were similar whether patients received induction immunotherapy with infliximab at weeks 0, 2, and 6, or on an accelerated...
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Study supports swallowed topical steroids as maintenance for eosinophilic esophagitis
- Author:
- Amy Karon
Rates of clinical remission were 16.1% and 1.3%, respectively (P less than .001).
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Vedolizumab, tofacitinib induced rapid improvements in IBD symptoms
- Author:
- Amy Karon
Two recent studies highlight the ability of vedolizumab and tofacitinib to rapidly improve symptoms reported by patients with inflammatory bowel...
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Study eyed endoscopic submucosal dissection for early-stage esophageal cancer
- Author:
- Amy Karon
Compared with esophagectomy, ESD was associated with significantly fewer severe adverse perioperative events and a similar rate of all-cause...
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Vedolizumab, tofacitinib induced rapid improvements in IBD symptoms
- Author:
- Amy Karon
Both biologics induced clinically meaningful improvements in patient-reported outcomes early in the course of treatment.
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Routine markers predicted histologic response to obeticholic acid in NASH
- Author:
- Amy Karon
Significant predictors included baseline nonalcoholic fatty liver disease activity score greater than 5, baseline triglycerides up to 154 mg/dL,...
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Staying up to date on screening may cut risk of death from CRC
- Author:
- Amy Karon
Staying up to date on screening was associated with a 62% decrease in the odds of dying from colorectal cancer.
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Budesonide topped placebo for treating lymphocytic colitis
- Author:
- Amy Karon
Fully 79% of patients achieved clinical remission with budesonide.
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Maintaining virologic response predicted long-term survival in HBV patients with decompensated cirrhosis
- Author:
- Amy Karon
An HBV DNA load less than 20 IU/mL in patients with decompensated cirrhosis significantly improved the chances of long-term survival.
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Norfloxacin might benefit patients with advanced cirrhosis and low ascites fluid protein levels
- Author:
- Amy Karon
The mortality benefit appeared to be limited to patients with ascites fluid protein levels under 15 g/L.
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Crohn’s disease tied to anal canal high-risk HPV infection
- Author:
- Amy Karon
High-risk HPV DNA was detected in anal tissue specimens from 30% of patients with Crohn’s disease versus 18% of patients without Crohn’s disease...