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Patient selection key to lowering placebo response rates in lupus clinical trials
High placebo response rates in lupus clinical trials are making it difficult to show treatment effectiveness.
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Strategies for complete B-cell depletion evolve for patients with lupus nephritis
Growing evidence suggests more complete B-cell depletion in patients with lupus nephritis is associated with a greater likelihood of treatment...
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Investigational lupus drug cenerimod moves to phase 3 studies after equivocal phase 2 results
Novel S1P1 receptor modulator cenerimod shows impact on disease activity in lupus, with more pronounced benefits in those with more severe disease...
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Early remission in lupus nephritis can still progress to advanced CKD
Patients with lupus nephritis who achieve complete remission within 1 year of starting treatment can still progress to advanced chronic kidney...
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Biomarkers for measuring lupus nephritis treatment response gain ground
A panel of protein biomarkers in urine could achieve better identification of lupus nephritis patients who are likely to respond to treatment.
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Running does not cause lasting cartilage damage
A single bout of running causes only transient and small changes to the thickness and structure of healthy cartilage in the knee.
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Ustekinumab matches TNF inhibitors for psoriatic arthritis in 3-year, real-world study
A real-world study comparing the interleukin-12/23 inhibitor ustekinumab with tumor necrosis factor inhibitors for psoriatic arthritis found...
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Hydroxychloroquine risk found in some older patients with RA
Hydroxychloroquine initiation in older patients with rheumatoid arthritis and a history of heart failure was associated with an increased risk of...
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Gout app improves treat to target, reduces flares
A smartphone app to help patients communicate their urate levels to clinicians means more achieve treatment targets and experience fewer flares....
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No excess mortality seen in contemporary undifferentiated arthritis
Patients who meet the contemporary criteria for undifferentiated arthritis do not appear to have an increase in excess mortality, unlike those who...
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Fewer diabetes complications with NOACs in patients with AFib
Taking non–vitamin K oral anticoagulants is associated with lower mortality and fewer diabetes complications vs. taking warfarin in patients with...
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Allopurinol found safe in patients with concomitant gout, CKD
Despite earlier concerns, a study has found no sign of increased mortality with allopurinol therapy in patients with gout and chronic kidney...
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Cardiac function normalizes by 3 months in MIS-C in study
Children with COVID-19–related multisystem inflammatory syndrome show normalization of cardiac function by 3 months after diagnosis.
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AI holds its own against pathologists for prostate cancer diagnosis
Deep learning algorithms have shown a high level of agreement with expert uropathologists in diagnosing and grading prostate cancer.
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Delays in cancer referral, diagnosis linked with morbidities
Patients with multiple morbidities were much more likely to have their cancer diagnosed at least 60 days after initial primary care consultation...