News
Thrombocytopenia signals multiorgan system failure in acute liver failure
- Author:
- Jennifer Shepphird
Key clinical point: In patients with acute liver failure (ALF), decreasing platelet counts were associated with systemic inflammation and greater...
News
SIRT plus FOLFOX chemo for mCRC improved progression-free survival in liver only
- Author:
- Jennifer Shepphird
Key clinical point: Selective internal radiation therapy (SIRT) combined with FOLFOX-based chemotherapy in patients with metastatic colorectal...
News
Muscle loss during chemotherapy predicts poor survival in metastatic colorectal cancer
- Author:
- Jennifer Shepphird
Key clinical point: Patients with metastatic colorectal cancer (mCRC) whose muscle mass dropped by 9% or more during chemotherapy had...
News
Low serum vitamin D may signal more aggressive prostate cancer
- Author:
- Jennifer Shepphird
Key clinical point: Serum 25-hydroxyvitamin D (25-OH D) deficiency was associated with greater risk for adverse pathology in men with localized...
News
Ponatinib effective in chronic phase CML regardless of baseline mutation status
- Author:
- Jennifer Shepphird
Key clinical point: Baseline mutation status had little impact on ponatinib response, and no single or compound mutation was a major driver of...
News
Panobinostat plus bortezomib and dexamethasone improved outcomes in previously treated multiple myeloma
- Author:
- Jennifer Shepphird
Key clinical point: Panobinostat plus bortezomib and dexamethasone improved outcomes in patients with previously treated multiple myeloma,...
News
Breast cancer patients at increased risk of colorectal cancer
- Author:
- Jennifer Shepphird
Key clinical point: Colorectal cancer risk was significantly increased in patients previously diagnosed with breast cancer. Major finding:...
News
Nanoparticles deliver Aurora kinase inhibitor with increased safety and efficacy
- Author:
- Jennifer Shepphird
Key clinical point: Aurora B kinase inhibitor nanoparticles displayed accumulation and retention in tumors with improved efficacy and minimal bone...
News
Lysolipid antigens prominent in MGUS and myeloma
- Author:
- Jennifer Shepphird
Key clinical point: In patients with Gaucher disease and in nearly one-third of patients with MGUS or myeloma, clonal immunoglobulins reacted with...
News
Defibrotide offers benefit for severe veno-occlusive disease and multiorgan failure
- Author:
- Jennifer Shepphird
Key clinical point: Defibrotide improved survival at 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hepatic veno-...
News
Resources limit availability of bone marrow transplants
- Author:
- Jennifer Shepphird
Key clinical point: In regions with limited resources, peripheral blood stem cells were used more frequently than bone marrow in hematopoietic...
News
Early mortality predicted by age and poor performance status in patients with colon cancer
- Author:
- Jennifer Shepphird
Key clinical point: Among patients with colon cancer enrolled in phase III trials for adjuvant therapy, mortality within 6 months of random...
News
Cola enhances absorption of erlotinib in NSCLC
- Author:
- Jennifer Shepphird
Key clinical point: Taking oral erlotinib with cola significantly increased the drug’s bioavailability in patients concomitantly taking the acid-...
News
High-dose interferon offered no survival benefit in patients with melanoma and a single tumor–positive sentinel lymph node
- Author:
- Jennifer Shepphird
Key clinical point: Adjuvant high-dose interferon (HDI) did not improve survival in patients with a single tumor–positive sentinel lymph node (SLN...
News
Patient prognostic score may lessen DCIS overtreatment
- Author:
- Jennifer Shepphird
Key clinical point: A recurrence risk score based on clinicopathologic features of ductal carcinoma in situ (DCIS) was associated with survival...