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Seventeen percent of breast cancer patients reclassified after risk score reassessment
Combining clinical risk factors with a polygenic risk score accounting for ancestral background substantially improves breast cancer risk...
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Outrage over dapagliflozin withdrawal for type 1 diabetes in EU
The voluntary withdrawal of the type 1 diabetes indication for dapagliflozin in the EU by AstraZeneca has been branded as ‘appalling’ and ‘...
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Sacituzumab govitecan effective in Black mTNBC patients
Black women may have outcomes comparable to those of other women when given sacituzumab govitecan for the treatment of metastatic TNBC, suggests...
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PD-L1 cutoff for pembrolizumab in mTNBC confirmed
PD-L1 CPS of at least 10 improves overall survival by 28%-29%. Further analysis of responses to pembrolizumab plus chemotherapy in metastatic TNBC...
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Pembrolizumab improves event-free survival in early TNBC
Neoadjuvant pembrolizumab benefits early TNBC patients regardless of disease stage and nodal status. Event-free survival improved by about 35%...
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Genomic instability varies between breast cancer subtypes
Personalized medicine could be a step closer with the discovery that TNBC and ER+ breast cancers should have different genomic instability...
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Does vitamin D benefit only those who are deficient?
The results will “allow clinicians to better weigh the potential benefits of supplementation against its risk,” such as financial cost.
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Surgery offers best chance in cancer but needs more ‘support’
“High-quality surgery remains the best chance to cure solid cancer when diagnosed early.”
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Antiepileptic medications linked to increased priapism risk
If clinicians encounter such cases of priapism, they should be “reported to the regulatory authorities,” said lead researcher Dr. Ana Pejcic.
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Art therapy linked to slowed Parkinson’s progression
The positive effect of art therapy could be related to “activating the brain’s reward neural network,” said Dr. Iryna Khubetova.
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‘Impressive’ results for novel antidepressant, so why the FDA delay?
Results showed the drug had a clinical response rate of 80% and a remission rate of almost 70%.
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Lower thyroid hormone levels a red flag for elevated suicide risk?
Patients with suicidal ideation were 54% less likely to have higher TSH levels.
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Steroid a promising short-term treatment option for major depression?
“These data continue to support the development of zuranolone as a potential 14-day short course treatment” for MDD episodes, said Dr. Colville...
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Constipation med boosts cognitive performance in mental illness
“Our study provides exciting early evidence in humans of a new approach that might be a helpful way to treat these residual cognitive symptoms.”...