M. Alexander Otto began his reporting career early in 1999 covering the pharmaceutical industry for a national pharmacists' magazine and freelancing for the Washington Post and other newspapers. He then joined BNA, now part of Bloomberg News, covering health law and the protection of people and animals in medical research. Alex next worked for the McClatchy Company. Based on his work, Alex won a year-long Knight Science Journalism Fellowship to MIT in 2008-2009. He joined the company shortly thereafter. Alex has a newspaper journalism degree from Syracuse (N.Y.) University and a master's degree in medical science -- a physician assistant degree -- from George Washington University. Alex is based in Seattle.
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Drug conjugate extends life in HER2+ end-stage metastatic colorectal cancer
An almost 50% response rate is “very exciting.”
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Study findings support consideration of second biopsy for transected melanomas
Accurate Breslow depth is necessary for surgical decisions.
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Mohs surgery favorable as monotherapy for early Merkel cell carcinomas
Small series adds to growing body of literature.
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Study supports intensifying chemoradiotherapy for head and neck cancer
Intensifying chemoradiotherapy appeared to improve outcomes in locally advanced head and neck cancer.
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Novel hedgehog inhibitor strategies improve BCC outcomes
Upfront tumor debulking seems to help.
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Checkpoint inhibitor skin side effects more common in women
"Clinicians should consider these results in counseling female patients regarding an elevated risk of dermatologic adverse events."
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Lobaplatin deemed ‘promising alternative’ to cisplatin in nasopharyngeal carcinoma
A lobaplatin-based regimen was as effective as a cisplatin-based regimen in a phase 3 trial.
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Survival benefit with nivolumab extends to 5 years in NSCLC
Early response portends durable outcome, but the optimal duration of treatment is uncertain.
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Cell-free DNA improves response prediction in breast cancer
Using cell-free DNA and MRI in combination improved prediction of pathological complete response.