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DHEA unable to turn the tide of ovarian aging
DHEA supplementation was no match for the powerful effects of ovarian aging in women with diminished ovarian reserve in the DITTO trial. Women who...
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Depression, stress don’t predict outcomes in recurrent pregnancy loss
Depression and emotional stress did not lead to poorer pregnancy outcomes 1-year after referral for recurrent pregnancy loss in a prospective,...
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Reasonable ovarian stimulation doesn’t increase preterm birth risk
There was no increased risk of preterm birth or low birth weight following in vitro fertilization via ovarian stimulation with 20 or fewer oocytes...
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CUDC-907 passes early hurdle in heavily pretreated lymphoma, myeloma
Key clinical point: The dual HDAC and Pi3K inhibitor CUDC-907 was reasonably tolerated and clinically active in a phase I study of heavily...
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Review shows D&C raises preterm birth risk
Dilation and curettage increases the risk for prematurity in subsequent pregnancy, according to a systematic review and meta-analysis of nearly 2...
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Expectant management holds its own in incomplete misoprostol miscarriage
Expectant management is a safe and effective treatment for incomplete miscarriage after misoprostol, results of the MisoREST trial show. “Because...
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Age drives miscarriage risk in RA patients
Key clinical point: Miscarriage rates are comparable in patients with rheumatoid arthritis and the general public and are driven largely by...
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GnRH-antagonist protocol trims ovarian hyperstimulation
Women undergoing assisted reproduction had similar pregnancy rates with gonadotropin-releasing hormone agonist and antagonist protocols, but less...
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ABA: Engineered skin substitutes trim pediatric burn mortality
Key clinical point: Availability of autologous engineered skin substitutes for treatment of extensive, deep burns may reduce time to wound closure...
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Top-down Crohn’s treatment holds up long term
Key clinical point: Top-down therapy for Crohn’s disease resulted in fewer flares and a longer time to first flare than did conventional...
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GLUTOX: Identifying nonceliac gluten sensitivity
Key clinical point: A randomized, double-blind dietary challenge may be useful in identifying nonceliac gluten sensitivity. Major finding: More...
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P13K inhibitors TGR-1202, duvelisib found clinically active in CLL
Key clinical point: The investigational P13K inhibitors TGR-1202 and duvelisib were clinically active in phase I trials. Major finding: TGR-1202...