Article
Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone?
EVIDENCE-BASED ANSWER: Yes. Monthly extended-release injectable naltrexone (XR-NTX) treats opioid use disorder as effectively as daily sublingual...
Article
Which oral nonopioid agents are most effective for OA pain?
EVIDENCE-BASED ANSWER: Nonsteroidal anti-inflammatory drugs (NSAIDs), when used at the maximum clinically effective dose, reduce osteoarthritis (...
Article
How often does long-term PPI therapy cause clinically significant hypomagnesemia?
EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory...
Article
What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events?
EVIDENCE-BASED ANSWER: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years (...
Article
What is the best beta-blocker for systolic heart failure?
EVIDENCE-BASED ANSWER: Three beta-blockers—carvedilol, metoprolol succinate, and bisoprolol—reduce mortality equally (by about 30% over one year)...
Article
Does surgery relieve the pain of a herniated disc?
EVIDENCE-BASED ANSWER: YES, in the short term. Patients with an acute episode of low back pain, radicular symptoms, and evidence of a herniated...
Article
What’s the best treatment for sebaceous cysts?
EVIDENCE-BASED ANSWER: Punch biopsy excision appears to be superior to traditional wide elliptical excision for the treatment of sebaceous cysts...
Article
Do preparticipation clinical exams reduce morbidity and mortality for athletes?
EVIDENCE-BASED ANSWER: Though clinical preparticipation exams (PPE) are recommended by experts and required in most states, we found no medium- or...