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Benefit from cooling temps for cardiac arrest does not differ in randomized trial
For major outcomes, cooling comatose cardiac arrest patients to 31° had no advantage over 34° in a controlled trial.
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GALACTIC-HF: Novel drug most effective in sickest HFrEF patients
In GALACTIC-HF trial, the greatest relative benefit of omecamtiv mecarbil was in the sickest HFrEF patients.
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Dapagliflozin misses as treatment for COVID-19 but leaves intriguing signal for benefit
The SGLT2 inhibitor dapagliflozin was not associated with significant benefit in COVID-19 patients but came close.
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FLOWER-MI: FFR-guided complete revascularization shows no advantage in STEMI
In STEMI patients, event rates following complete revascularization guided by fractional flow reserve or angiography were similar.
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Nasal spray resurrected after showing clinical benefits for PSVT
After missing its trial endpoint, etripamil, a treatment for paroxysmal supraventricular tachycardia, still appears beneficial.
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In pemphigus, phase 2 results with BTK inhibitor raise hopes for phase 3 trial
The well tolerated BTK inhibitor rilzabrutinib might be the first, but not last BTK inhibitor for pemphigus vulgaris. “The improvement...
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For diagnosing skin lesions, AI risks failing in skin of color
AI-aided diagnostic algorithms will not work in skin of color if machine training remains inadequate.
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Experts say teledermatology’s postpandemic role is unclear
There are many unknowns, not least of which is future reimbursement from the Centers for Medicare & Medicaid Services and other third-party...
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Topical anticholinergic for axillary hyperhidrosis shows fewer side effects
The agent, which shows strong activity at the application site but reduced systemic activity, is moving through the U.S. regulatory process.
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Systematic approach to pain helps avoid opioid issues for dermatologists
For most skin diseases, dermatologists should take the lead for pain management, but there are exceptions.
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In low-risk thyroid cancer, no advantage found for postsurgical iodine
Forgoing postoperative radioactive iodine in low-risk differentiated thyroid cancer is supported by phase 3 data.
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Denosumab now dominant therapy for osteoporosis linked to cancer
In changing patterns of osteoporosis drug prescriptions, denosumab has risen to the top of cancer indications.
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Obesity pegged as source of marked increased risk of diabetes in PCOS
Obesity has been identified as the key risk factor for type 2 diabetes in women with polycystic ovary syndrome in a new study. It suggests that...