Women with ER-positive breast Ca may soon extend tamoxifen therapy to 10 years

Side effects were more common among postmenopausal women

Although tamoxifen has some side effects, they had a relatively small net effect on survival. The most significant effect was an increased risk—among postmenopausal women—of endometrial cancer. However, the excess risk of dying of endometrial cancer by year 15 was only 0.2% (0.4% among women who continued tamoxifen to 10 years vs 0.2% in the control group).

Investigators found no evidence that tamoxifen increases the risk of stroke, despite the fact that the US Food and Drug Administration lists stroke as a possible side effect of the drug.

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