Limitations
- The study used a cross-sectional design, which is not suited to making causal inferences.
- The authors characterized DPN as either present or absent. They did not evaluate or analyze the severity of peripheral neuropathy.
- The authors evaluated diabetic cardiac autonomic neuropathy (DCAN) by a person’s coefficient of variation of R-R intervals, and definitive diagnosis of DCAN required at least two positive results on a cardiac autonomic test. More vigorous evaluation using a more definitive assessment of DCAN is needed to relate DCAN and IAH status.
Disclosures
- The study received no commercial funding.
- The authors have disclosed no relevant financial relationships.
This is a summary of a preprint research study, “Protective and risk factors of impaired awareness of hypoglycemia in patients with type 1 diabetes: a cross- sectional analysis of baseline data from the PR-IAH study,” written by researchers at several hospitals in Japan, all affiliated with the National Hospital Organization, on Research Square. The study has not yet been peer reviewed. The full text of the study can be found on researchsquare.com.
A version of this article first appeared on Medscape.com.