CE/CME

Interstitial Cystitis: A Painful Syndrome

Clinician Reviews. 2013 July;23(7):30-37

Author(s):

Although accreditation for this CE/CME activity has expired, and the posttest is no longer available, you can still read the full article.

Expires July 31, 2014
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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common, painful disease  of the urinary bladder. Difficult to diagnose and frequently misdiagnosed as another  common urologic disorder, IC/BPS challenges health care providers to identify it  early and implement current treatment algorithms that may simplify management  and improve quality of life for affected patients.

References

1. Dasgupta J, Tincello DG. Interstitial cystitis/bladder pain syndrome: an update. Maturitas. 2009;64:212-217.

2. Hanno PM, Burks DA, Clemens JQ, et al. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: American Urological Association (AUA) Guideline (2011). www.auanet.org/education/guidelines/ic-bladder-pain-syndrome.cfm. Accessed June 5, 2013.

3. Evans RJ; University of Tennessee Advanced Studies in Pharmacy. Pathophysiology and clinical presentation of interstitial cystitis (2005). www.utasip.com/files/articlefiles/pdf/XASIP_Issue_Mar_p8_14.pdf. Accessed June 5, 2013.

4. Sant GR. Etiology, pathogenesis, and diagnosis of interstitial cystitis. Rev Urol. 2002;(4 suppl 1):S9-S15.

5. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21:167-178.

6. van de Merwe JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53:60-67.

7. Bogart LM, Berry SH, Clemens JQ. Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review.  J Urol. 2007;177:450-456.

8. Kusek JW, Nyberg LM. The epidemiology of interstitial cystitis: is it time to expand our definition? Urology. 2001;57(6 suppl 1):95-99.

9. Clemens JQ, Meenan RT, Rosetti MC, et al. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol. 2005;173:98-102.

10. Berry SH, Elliott MN, Suttorp M, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186:540-544.

11. Rosamilia A, Dwyer PL. Pathophysiology of interstitial cystitis. Curr Opin Obstet Gynecol. 2000;12:405-410.

12. Grover S, Srivastava A, Lee R, et al. Role of inflammation in bladder function and interstitial cystitis. Ther Adv Urol. 2011;3:19-33.

13. Rosenberg MT, Page S, Hazzard MA. Prevalence of interstitial cystitis in a primary care setting. Urology. 2007;69(4 suppl):S48-S52.

14. Evans RJ. Treatment approaches for interstitial cystitis: multimodality therapy. Rev Urol. 2002;(4 suppl 1):S16-S20.

15. Wesselmann U. Interstitial cystitis: a chronic visceral pain syndrome. Urology. 2001;57(6 suppl 1):102.

16. Hosseini A, Ehrén I, Wiklund NP. Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis.  J Urol. 2004;172(6 pt 1):2261-2265.

17. Ho MH, Bhatia NN, Khorram O. Physiologic role of nitric oxide and nitric oxide synthase in female lower urinary tract. Curr Opin Obstet Gynecol. 2004;16:423-429.

18. Rosenberg MT, Newman DK, Page SA. Interstitial cystitis/painful bladder syndrome: symptom recognition is key to early identification, treatment. Cleve Clin J Med. 2007;74:854-862.

19. Driscoll A, Teichman JM. How do patients with interstitial cystitis present?  J Urol. 2001;166:2118-2120.

20. Parsons CL. Interstitial cystitis: epidemiology and clinical presentation. Clin Obstet Gynecol. 2002;45:242-249.

21. Hanno PM, Landis JR, Matthews-Cook Y, et al. The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database study. J Urol. 1999;161:553-557.

22. Whitmore KE, Theoharides TC. When to suspect interstitial cystitis. J Fam Pract. 2011;60:340-348.

23. Butrick CW, Howard FM, Sand PK. Diagnosis and treatment of interstitial cystitis/painful bladder syndrome: a review. J Womens Health (Larchmt). 2010;19:1185-1193.

24. O’Leary MP, Sant GR, Fowler FJ Jr, et al. The interstitial cystitis symptom index and problem index. Urology. 1997;49(5A suppl):58-63.

25. Nickel JC. Forensic dissection of a clinical trial: lessons learned in understanding and managing interstitial cystitis. Rev Urol. 2010;12:e78-e85.

26. Anger JT, Zabihi N, Clemens JQ, et al. Treatment choice, duration, and cost in patients with interstitial cystitis and painful bladder syndrome. Int Urogynecol J. 2011;22:395-400.

27. Nickel JC. Interstitial cystitis: characterization and management of an enigmatic urologic syndrome. Rev Urol. 2002;4:112-121.

28. Dell JR. Interstitial cystitis/painful bladder syndrome: appropriate diagnosis and management. J Womens Health (Larchmt). 2007;16:1181-1187.

29. National Kidney and Urologic Diseases Information Clearinghouse. Interstitial cystitis/painful bladder syndrome (2011). NIH Publication No. 11–3220. http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/IC_PBS_T_508.pdf. Accessed June 5, 2013.

30. Davis EL, El Khoudary SR, Talbott EO, et al. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179:177-185.

31. Pinto R, Lopes T, Silva J, et al. Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome/interstitial cystitis. J Urol. 2013;189:548-553.

32. Pinto R, Lopoes T, Frias B, et al. Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome/interstitial cystitis. Eur Urol. 2010;58:360-365.

33. Gottsch HP, Miller JL, Yang CC, Berger RE. A pilot study of botulinum toxin for interstitial cystitis/painful bladder syndrome. Neurourol Urodyn. 2011; 30:93-96.

34. Neuhaus J, Schwalenberg T, Horn LC, et al. New aspects in the differential diagnosis and therapy of bladder pain syndrome/interstitial cystitis. Adv Urol. 2011;2011:639479.