Celecoxib Gets Another Look

In the recently published Celecoxib Versus Omeprazole and Diclofenac in Patients With Osteoarthritis and Rheumatoid Arthritis (CONDOR) trial, investigators compared the risk of gastrointestinal (GI) events associated with cyclo-oxygenase (COX)-2-selective non-steroidal anti-inflammatory drugs (NSAIDs) vs nonselective NSAIDs plus a proton-pump inhibitor. They found the rate of clinically significant GI events was 4 times higher in study participants taking diclofenac plus omeprazole than in those taking celecoxib.