Aspirin and Prednisolone Cotherapy: Few GI AEs

Aspirin and prednisolone are both associated with adverse gastrointestinal events, so cotherapy might be expected to intensify that potential. Studies have indicated a probable “moderate” interaction between aspirin and corticosteroids, based on the pharmacokinetic interaction of the 2 drugs, say researchers from National University of Singapore and National Cancer Centre Singapore. However, they say the prevalence and clinical significance of interaction-induced GI events in cancer patients are relatively unknown. Their retrospective analysis of data from 142 cancer patients suggests that the clinical impact of any aspirin-prednisolone drug-drug interaction is minimal.