There appears to be a link between vitamin D insufficiency (VDI) and early clinical failure in patients with follicular lymphoma, according to an observational prospective cohort study involving 642 individuals. Participants had follicular lymphoma that was diagnosed at a median of 60 years of age between 2002 and 2012. Investigators looked at whether VDI was linked with adverse outcomes. Among the results:

• At a median follow-up of ~5 years, 46% of patients experienced either an event or treatment failure.
• 7% had a lymphoma-related death.
• Overall, patients with VDI were more than twice as likely to experience inferior event-free survival at 1 year; the same was true for overall survival.
• They were nearly 3 times more likely to experience inferior lymphoma-specific survival.
• Among patients treated with immunochemotherapy, those with VDI were ~3 times more likely to experience inferior event-free survival; the same was true for overall survival.
• They were nearly 6 times more likely to experience inferior lymphoma-specific survival.