Pharmacology
News
In adults with prediabetes, vitamin D cuts diabetes risk
Vitamin D reduced the risk for diabetes in people with prediabetes by a statistically significant 15%, in a meta-analysis.
News
FDA OKs sacituzumab govitecan for HR+ metastatic breast cancer
Label expansion for the Trop-2–directed antibody-drug conjugate was based on the TROPICS-02 trial.
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Despite limits, COVID vaccines protect CLL patients
A small German study found that, in patients with CLL, COVID-19 shots don’t boost B cells but they do strengthen T cells.
News
First Humira biosimilar launches in U.S.
Amgen’s Amjevita will be offered at 5% and 55% below Humira’s list price, but patients may not benefit from the more significant discount.
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Angioedema risk jumps when switching HF meds
The risk for angioedema rises when switching from an ARB or ACE inhibitor to ARNI, observational data suggest.
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FDA approves pirtobrutinib for r/r mantle cell lymphoma
Pirtobrutinib for relapsed or refractory mantle cell lymphoma has been approved by the Food and Drug Administration.
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Eye check important before starting semaglutide for diabetes
Meta-analysis finds small increased risk of retinopathy worsening after starting injectable semaglutide.
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PCSK9 inhibitors for severe COVID? Pilot trial signals of benefit
“PCSK9 inhibition may represent a novel therapeutic pathway in addition to currently recommended therapeutic approaches for severe COVID-19.”
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FDA approves new type 2 diabetes drug bexagliflozin
Another SGLT2 inhibitor has been approved for type 2 diabetes based on results from 23 clinical trials in 5,000 patients.
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Adding venetoclax improves ibrutinib outcomes in CLL
A small study yields sanguine news about a combination treatment, as hematologists await phase 3 results.