Conclusions
Hereditary CRC syndromes are becoming increasingly important to identify, especially in an era where we are seeing rising rates of early-onset CRC. Early identification of high-risk features (Table 2) can lead to timely diagnosis with the goal to implement preventive strategies for screening and/or surveillance, ideally prior to development of cancers.
As gastroenterologists, we have several unique opportunities to identify these individuals and must maintain a high level of suspicion with careful attention when obtaining personal and family history details in clinic and in endoscopy.
Dr. Maratt is assistant professor, Indiana University, Richard L. Roudebush VA Medical Center, Indianapolis. Dr. Stoffel is assistant professor, University of Michigan; director of Cancer Genetic Clinic, Rogel Cancer Center, Ann Arbor. They have no conflicts of interest.
References
1. Pearlman R et al. JAMA Oncol. 2017;3(4):464-71.
2. Stoffel EM et al. Gastroenterology. 2018;154(4):897-905.
3. Kanth P et al. Am J Gastroenterol. 2017;112:1509-25.
4. Brennan B et al. Ther Adv Gastroenterol. 2017;10:361-71.
5. National Comprehensive Cancer Network. Available at: nccn.org.
6. Lynch HT et al. Nat Rev Cancer. 2015;15:181-94.
7. Syngal S et al. Am J Gastroenterol. 2015;110:223-62.
8. Mankaney G et al. Clin Gastroenterol Hepatol. 2020:(in press)
9. Yan HHN et al. Gut 2017;66:1645-56.
10. Ma H et al. Pathology. 2018;50:49-59.
11. Vasen H et al. Gastroenterology 1999;116:1453-6.
12. Umar A et al. J Natl Cancer Inst. 2004;96:261-8.
13. Kastrinos F et al. J Natl Cancer Inst. 2015;108(2):1-9.
14. Chen S et al. JAMA. 2006;296(12):1479-87.
15. Barnetson RA et al. N Engl J Med. 2006;354(26):2751-63.
16. Kastrinos F et al. J Clin Oncol. 2017;35:2165-72.
17. Kastrinos F et al. Fam Cancer. 2018;17:567-67.
18. Cohen SA et al. Annu Rev Genomics Hum Genet. 2019;20:293-307.
19. Matloff J et al. J Natl Compr Canc Netw. 2013;11:1380-5.
20. Ladabaum U et al. Ann Intern Med. 2011;155(2):69-79.
21. Hampel H et al. N Engl J Med. 2005;352(18):1851-60.
22. Yurgelun MB et al. Cancer Prev Res. 2012;5:574-82.
23. Kastrinos F et al. Am J Gastroenterol. 2009;104:1508-18.
24. Luba DG et al. Clin Gastroenterol Hepatol. 2018;16:49-58.
25. Guivatchian T et al. Gastrointest Endosc. 2017;86:684-91.
