AML
Conference Coverage
Molecule shows preclinical activity in leukemias, lymphomas
SAN DIEGO—A small molecule that has previously proven effective against solid tumors exhibits activity against leukemias and lymphomas,...
Conference Coverage
Dual kinase inhibitor targets heterogeneity in AML
The inhibitor, SEL24-B489, targets both PIM and FLT3 mutants.
News
Compound is potent FLT3 inhibitor, team says
Credit: Rhoda Baer An experimental compound called TTT-3002 could be “one of the most potent FLT3 inhibitors to date,” according to researchers...
News
Product gets orphan designation for AML
The US Food and Drug Administration (FDA) has granted orphan designation for eryaspase to treat acute myeloid leukemia (AML). Eryaspase, also...
News
Testing reveals abnormalities in CN-AML/MDS
Credit: NIGMS NASHVILLE—New research suggests we may need to use more sensitive methods to analyze patients with cytogenetically normal acute...
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Monosomal karyotype, high prognostic risk score predicted transplantation failure
Major finding: Patients with a monosomal karyotype had a 49% relapse rate and a 10% 5-year overall survival rate, and those considered high or...
News
Group grows functional LSCs in culture
Two small-molecule compounds can help researchers maintain leukemic stem cells (LSCs) in culture, according to a paper published in Nature Methods...
Conference Coverage
CNS involvement doesn’t affect survival after allo-SCT
By analyzing transplant outcomes in more than 5000 patients, researchers found that subjects with CNS AML had rates of relapse and survival that...
News
Drugs get orphan designation for AML, MM
Credit: FDA The US Food and Drug Administration (FDA) has granted orphan designation for the histone deacetylase (HDAC) inhibitor pracinostat to...
News
Investigating the cause of infant leukemias
Results of whole-exome sequencing suggested that infants with leukemia inherited genetic variants from both parents that, by themselves, would not...
News
Protein may be target for AML treatment
The protein WTAP could play an important role in the development of acute myeloid leukemia (AML), according to new research. Investigators...