Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity of potentially curative cancer therapy regimens. Cisplatin is the class of chemotherapy agent that has a broad spectrum of activity against several solid tumors, but it induces sensory neuropathy of upper and lower extremities. Cisplatin-induced peripheral neuropathy is usually in a “gloves and socks” distribution that can persist for months or years after completion of chemotherapy treatment. If the pain is severe, it affects the patient’s long-term quality of life and can potentially result in chemotherapy dose reduction or treatment discontinuation.
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