Cellular Therapy
Conference Coverage
Ultrasound method predicts liver complications in pediatric transplant
HOUSTON – Using shear wave elastography predicted disease at least 4 days before standard diagnostic criteria in most patients.
From the Journals
Haplo-HCT shows viability in DLBCL
Survival rates were similar for matched and unmatched donors.
Conference Coverage
PD-1 blockade plus CD19 CAR T boosts CAR T-cell persistence
SAN DIEGO – The combination appears to bolster CAR T-cell effects and persistence in children with relapsed B-ALL.
Conference Coverage
Novel bispecific CAR shows promise in B-cell malignancies
SAN DIEGO – This is the first in-human study of a bispecific loop CAR in the United States.
Conference Coverage
Uninterrupted ibrutinib with CAR T could improve CLL outcomes
SAN DIEGO – Ibrutinib treatment before and after CAR T-cell therapy in CLL patients may decrease the risk of severe cytokine release syndrome.
Conference Coverage
Armored CAR protects T cells, induces remissions
SAN DIEGO – A CAR T-cell construct engineered to enhance T-cell persistence and immune function induced high complete remission rates in a phase 1...
Conference Coverage
Long-term side effects of CAR T cells mostly mild
SAN DIEGO – Follow-up of patients who survived at least 1 year after CAR T-cell infusions suggests that the technology is safe.
Conference Coverage
Lack of gut diversity hurts survival after HCT
SAN DIEGO – Patients with low diversity of intestinal microflora have worse overall survival after hematopoietic cell transplant.
Conference Coverage
TOURMALINE-MM3: Ixazomib improves PFS after myeloma transplant
SAN DIEGO – A leading investigator put the results in perspective with the currently approved lenalidomide, and the audience questions as to...
Video
JULIET: CAR T cells go the distance in r/r DLBCL
SAN DIEGO – Median overall survival among patients with complete responses to CAR-T cell therapy in the JULIET trial has not been reached.
Video
Gut bacteria influence HCT outcomes
SAN DIEGO – Gut microbiome diversity predicts overall survival after hematopoietic cell transplant.