CLL
From the Journals
ICYMI: Ibrutinib/rituximab combo improves CLL survival
Progression-free and overall survival were superior in patients receiving ibrutinib and rituximab, compared with standard chemotherapy.
From the Journals
BTK mutations linked to CLL progression on ibrutinib
The findings support mutational analysis in CLL patients on ibrutinib, according to researchers.
News
FDA approves rituximab biosimilar for cancer, autoimmune disorders
The biosimilar is approved for certain cancers and autoimmune disorders, although, like its reference drug, it comes with a boxed warning from the...
From the Journals
Ibrutinib-venetoclax found highly active in hard-to-treat CLL
Trial results suggest the two drugs may have synergistic efficacy when used together, and raise the possibility of achieving MRD negativity with...
Opinion
Potential improvements in convenience, tolerability of hematologic treatment
Dr. Alan P. Lyss dissects the practice changing elements of the COLUMBA trial in multiple myeloma and the ASCEND trial in CLL.
Conference Coverage
Acalabrutinib extends PFS in advanced CLL
AMSTERDAM – Monotherapy with the Bruton tyrosine kinase inhibitor acalabrutinib offered better progression-free survival, compared with rituximab-...
Conference Coverage
Ibrutinib tops chlorambucil against CLL
AMSTERDAM – The Bruton’s tyrosine kinase inhibitor was associated with a halving of risk for death, compared with chlorambucil.
From the Journals
Hedgehog signaling offers prognostic, therapeutic potential in CLL
Hedgehog signaling was associated with expression of GLI1, which could be a future therapeutic target.
Conference Coverage
Fixed-duration venetoclax-obinutuzumab superior to standard CLL therapy
CHICAGO – The immediately practice changing study offers a time-limited frontline option, one expert reported.
From the Journals
Venetoclax plus ibrutinib appears to suit elderly and high-risk patients with CLL
The combination of venetoclax and ibrutinib outperformed previous reports of either of the two agents alone.
From the Journals
Genetic analysis identifies prognostic markers in CLL
A single 11q22 deletion, lacking an ATM mutation on the other allele, had the shortest progression-free survival among patients with CLL who were...