CNS/Brain Cancer
Conference Coverage
Entrectinib exhibits activity in children with solid tumors
Entrectinib produced responses in patients who had fusions or mutations in target genes.
Conference Coverage
Liquid biopsy falls short for isolated brain lesions in lung cancer
GENEVA – Plasma circulating tumor DNA analysis detected molecular abnormalities in almost all patients with systemic...
Conference Coverage
MRI predicts ALK status of NSCLC via brain lesions
GENEVA – Radiogenomic MRI signatures may be useful in identifying ALK-positive brain metastases in NSCLC, allowing...
From the Journals
Combo shows promise in HER2-positive breast cancer with brain mets
Neratinib-capecitabine showed favorable efficacy outcomes, but also high toxicity, in patients with HER2-positive breast cancer and brain...
From the Journals
FDA Expanded Access benefits heavily pretreated patients, especially children
Although approximately 2% of cancer cases at Memorial Sloan Kettering Cancer Center are pediatric, 34.1% of single-patient uses of investigational...
From the Journals
Ibrutinib-MTX-rituximab combo shows promise in CNS lymphoma
The researchers proposed an 840-mg dose of ibrutinib in future studies.
From the Journals
Sex differences provide insight into glioblastoma treatment
According to a quantitative imaging and molecular analysis of 63 patients with glioblastoma, women appear to fare better than men with standard-of...
From the Journals
Proposed neuroblastoma classification scheme hinges on telomere maintenance mechanisms
Genomic analysis showed telomere maintenance mechanisms, RAS mutations, and p53 mutations were strongly associated with outcome and other disease...
From the Journals
Stereotactic radiotherapy highly effective for brain mets in RCC
Stereotactic radiotherapy is highly effective for controlling brain metastases in patients with renal cell carcinoma, even in those with more than...
From the Journals
SRS beats surgery in early control of brain mets, advantage fades with time
Patients undergoing complete surgical resection for brain mets were at much higher risk of local recurrence than patients.
From the Journals
Circulating tumor DNA identified by fragment size
Circulating tumor DNA in plasma is more likely to be within certain fragment size ranges, which could enable its detection and use in cancer...