Immuno-oncology
From the Journals
Adverse effects of PD-1/PD-L1 inhibitors varied by tumor type in systematic review
Patients with melanoma who received PD-1/PD-L1 inhibitors were significantly more likely to develop colitis, diarrhea, pruritus, and rash,...
News
FDA approves nivolumab for metastatic CRC
The indication includes patients aged 12 years and older with mismatch repair deficient and microsatellite instability high metastatic colorectal...
News
Enasidenib gets FDA approval for AML with IDH2 mutations
“Idhifa is a targeted therapy that fills an unmet need for patients with relapsed or refractory AML who have an IDH2 mutation,” said Richard...
Feature
New SU2C translational team aims to apply CAR T-cell therapy to pancreatic cancer
Can CAR T-cell therapy make a difference in hard-to-treat pancreatic cancer?
Conference Coverage
Pembrolizumab takes on r/r PMBCL
LUGANO, SWITZERLAND – Keynote 170 investigators are enrolling adults with relapsed/refractory PMBCL who are either ineligible for ASCT following...
Conference Coverage
Avelumab induces response in Hodgkin lymphoma after failed allo-SCT
LUGANO, SWITZERLAND – The immune checkpoint inhibitor avelumab showed efficacy against classical Hodgkin lymphoma among patients with disease...
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IMiD/Anti-CD20 combo induces complete responses in r/r NHL
Lugano, Switzerland – A combination of obinutuzumab (Gazyva) and the experimental immunomodulatory agent CC-122 showed “clinically meaningful”...
News
All FDA panel members go thumbs up for CTL019 in relapsed/refractory childhood ALL
Steps need to be taken to mitigate the risk of cytokine release syndrome and neurologic events and the potential for secondary malignancies.
Conference Coverage
VIDEO: Immune therapy effective, durable in treatment-naive melanoma brain metastases
CHICAGO – For patients with asymptomatic brain metastases from melanoma who had not had prior treatment, nivolumab combined with ipilimumab...
Conference Coverage
VIDEO: Immunotherapy ups disease control rate in relapsed mesothelioma
CHICAGO – Early data from a phase II trial of immune checkpoint inhibitors to treat relapsed mesothelioma give hope that immunotherapy may be an...
Conference Coverage
VIDEO: Combined immunotherapy strategy shows promise in advanced solid tumors
CHICAGO – IgG1 agonist monoclonal antibody plus nivolumab induced durable partial responses in patients with tumors thought to be insensitive to...