Myelodysplastic Syndrome
News
Inhibitor could treat range of hematologic disorders
A small molecule that targets the sonic Hedgehog signaling pathway has advanced to phase 2 trials in a range of hematologic disorders. In a phase...
News
Genetic mutation identifies favorable prognosis MDS
Mutations in SF3B1 identify a subset of patients with MDS with favorable prognosis.
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Clonal hematopoiesis explored in aplastic anemia
Key clinical point: Clonal hematopoiesis was detected in 47% of 439 patients with aplastic anemia, and some of the mutations were related to...
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CD8 cell dose predicts outcomes in allogeneic stem cell transplantation with reduced-intensity conditioning
Key clinical point: High CD8 cell dose in peripheral blood stem cell grafts was associated with reduced risk of relapse and increased survival in...
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ASCO: PERSIST-1 – pacritinib tops best available therapy in myelofibrosis
Key clinical point: Pacritinib is superior to best available therapy for alleviating splenomegaly and other symptoms of myelofibrosis. Major...
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Dexrazoxane Tx did not affect overall survival in pediatric leukemia and lymphoma
Key clinical point: Treatment with dexrazoxane was not associated with an increased risk for cancer relapse or death. Major finding: For pediatric...
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Team links telomere degeneration and MDS
telomeres in green Image by Claus Azzalin New research has revealed a direct link between telomere degeneration and myelodysplastic syndromes (...
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Drug can alleviate transfusion dependence in non-del-5q MDS
Photo courtesy of Celgene WASHINGTON, DC—Results of a phase 3 trial support the use of lenalidomide in patients with lower-risk myelodysplastic...
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Inhibitor improves OS in poor-prognosis MDS
WASHINGTON, DC—A small-molecule inhibitor can improve overall survival (OS) in certain patients with previously treated myelodysplastic syndromes...
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Drug shows promise for lower-risk MDS
WASHINGTON, DC—An investigational drug can increase hemoglobin levels and eliminate transfusion dependence in patients with lower-risk...