Transfusion Medicine
From the Journals
Mitapivat elicits positive response in pyruvate kinase deficiency
The safety data from this phase 2 study suggest that mitapivat could be administered long term for patients with pyruvate kinase deficiency.
Guidelines
New transfusion guidelines for thalassemia
Experts discussed recommendations for alpha and beta thalassemia as well as non–transfusion dependent thalassemia.
From the Journals
Preeclampsia doubles risk of postpartum transfusion reactions
The findings suggest that heightened attention should be paid when women with preeclampsia are evaluated for blood transfusions post partum.
From the Journals
Timing, volume of transfusion may not matter in children with severe anemia
The TRACT trial showed no significant differences in 28-day mortality or other clinical outcomes by transfusion timing or volume.
Conference Coverage
Durable transfusion independence in MDS with imetelstat
AMSTERDAM – The telomerase inhibitor may also have disease-modifying properties, investigators suspect.
From the Journals
Past donor pregnancy, sex do not affect transfusion-related mortality
A retrospective analysis of more than 1 million red blood cell transfusion recipients found that there was no significant increase in mortality...
Conference Coverage
C3 inhibitor shows potential in PNH and AIHA
GLASGOW – Researchers presented early results from the PADDOCK and PLAUDIT trials, showing that APL-2 significantly increased hemoglobin levels...
News
FDA examines changing donation policies for men who have sex with men
New strategies could replace current deferral time windows with behavioral criteria. The agency is planning a pilot study to see if a short risk...
News
FDA committee advises status quo for blood supply Zika testing
Conference Coverage
Novel transplant regimen improves survival in primary immunodeficiency
HOUSTON – Allo-HCT following a novel reduced-intensity conditioning regimen was largely successful in an NIH study of adults and children with...
From the Journals
Regimen shows promise as salvage for classical HL
Most patients studied responded to the regimen.