Translational Research
Commentary
FOUND IN TRANSLATION Minimal nomenclature and maximum sensitivity complicate MRD measures
Real time quantitative polymerase chain reaction (RT-qPCR) and next generation sequencing (NGS) requires a leukemia-specific abnormality but has...
News
10 recommendations for the Cancer Moonshot
Responding to the Cancer Moonshot initiative, a panel of scientists, clinicians, patient advocates, and industry representatives has issued 10...
News
Dasatinib plus venetoclax shows promise in mouse model of Ph+ALL
The combination of dasatinib and venetoclax shows promise for the treatment of primary Philadelphia chromosome–positive acute lymphoblastic...
News
The liver drives RBC elimination, iron recycling
News
Dematin key to erythrocyte membrane stability in mice
Key clinical point: Dematin is newly recognized as a protein crucial to the integrity of red blood cell membranes. Major finding: Dematin’s...
News
CUDC-907 enters phase II for relapsed or refractory lymphoma and multiple myeloma
Key clinical point: The CUDC-907 dose to be used in phase II studies will be 60 mg on a 5-days-on/2-days-off dosing schedule. Major finding: Two...
News
Nanoparticles deliver Aurora kinase inhibitor with increased safety and efficacy
Key clinical point: Aurora B kinase inhibitor nanoparticles displayed accumulation and retention in tumors with improved efficacy and minimal bone...
News
Novel test detects low levels of residual CML
Key clinical point: A novel test may predict which CML patients in remission can safely stop TKI therapy. Major finding: Digital PCR for BCR-ABL1...
News
Consensus document issued on hematology research priorities for Europe
News
Blocking two targets boosted fetal hemoglobin expression
New findings related to fetal globin expression could open the door to novel therapies for adults with sickle cell disease and thalassemia.
Conference Coverage
ASH: Novel GBT440 reduces sickle cells, improves hematologic parameters
Key clinical point: A first-in class small molecule drug improved hematologic parameters and reduced sickling of red blood cells.