Alzheimer's & Cognition
News
Brain memory signals appear to regulate metabolism
"Our study is the first to show how clusters of brain cell firing in the hippocampus may directly regulate metabolism."
Feature
Novel antidepressant shines in phase 2 trial, but FDA has issues with its NDA
In the MERIT study, AXS-05 significantly delayed time to depression relapse compared with placebo, which was their primary endpoint.
Conference Coverage
COVID-19 tied to acceleration of Alzheimer’s disease pathology
Patients with Alzheimer’s disease are at threefold higher risk for COVID infection and have a twofold higher risk for death.
Conference Coverage
‘Alarming’ data on early cognitive decline in transgender adults
“Trans populations are disproportionately impacted by health disparities and also risk factors for dementia.”
Conference Coverage
Low-dose aspirin linked to lower dementia risk in some
Two cohorts suggest long-term use may be beneficial, but primarily in those with cardiovascular risk.
Conference Coverage
Short sleep is linked to future dementia
Decades of follow-up suggest sleep disruption is a true risk factor, not a warning sign.
Conference Coverage
‘Staggering’ increase in global dementia cases predicted by 2050
Estimates of expected increases can and should inform policy and planning efforts, researchers say.
From the Journals
Coffee and the brain: ‘Concerning’ new data
High levels of consumption may have adverse long-term effects on the brain.
Conference Coverage
First guidance on appropriate use of controversial Alzheimer’s drug
“This is a first-in-class drug where the vast majority of clinicians have no experience with it.”
Conference Coverage
Dementia caregivers benefit from telehealth support
Delivery of an intervention to improve caregiver quality of life was equivalent to in-person delivery.
From the Journals
More on GRADE: Cognitive deficits linked to CV risk factors in T2D
Hyperlipidemia and hypertension predict modest cognitive impairment even in diabetes of limited duration, but one expert urges caution: “The...