The median T2:ERG score was higher in patients who had a Gleason score of 7 or greater, involvement of more than 50% of positive cores by cancer, and three or more positive cores.
“The T2:ERG assay significantly improved the diagnostic accuracy of a logistic regression model” for prostate cancer detection, Dr. Amberson said.
The area under the curve was 0.597 for serum PSA level alone, 0.715 for a model using multiple risk factors (serum PSA level, percentage of free PSA, age, prostate volume, family history, race, digital rectal examination result, prior biopsy history, and urine prostate cancer gene 3 level), and 0.754 when the T2:ERG score was added to the model.