Conference Coverage

Asians have highest rate of herbal dietary supplement DILI liver transplantations


 

FROM THE LIVER MEETING 2017

There is a significant relationship between race/ethnicity and drug-induced liver disease requiring liver transplantation caused by herbal and dietary supplements (HDS), according to a study presented at the annual meeting of the American Association for the Study of Liver Diseases.

human liver Wavebreakmedia Ltd/ThinkStockPhotos.com
Data for the study were gathered from the Organ Procurement and Transplantation Network database, using a primary diagnosis of acute hepatic necrosis. A total of 645 patients were included in the final analysis, split into an HDS drug-induced liver injury (DILI) group and a non–HDS DILI group, Varun Kesar, MD, of Lenox Hill Hospital in New York and his associates noted.

Asian people had significantly higher rates of HDS DILI that required transplant than did blacks, Hispanics, whites, and others (American Indian/Alaskan native, multiracial, and native Hawaii/Pacific Islander). White people had significantly lower rates of HDS DILI than did blacks, Hispanics, and others.

While the proportion of white people with HDS DILI requiring transplant was much lower than other races/ethnicities, the rate from 2005 to 2015 was significantly higher in this population than in 1995-2005, Dr. Kesar and his colleagues noted.

Dr. Odin is a member of Intercept Pharmaceuticals advisory committees or review panels and is an AASLD member. Dr. Ahmad is an AASLD member.

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