From the Journals

Can colorectal ESD succeed in outpatient settings?


 

FROM GASTROINTESTINAL ENDOSCOPY

Endoscopic submucosal dissection to remove large colorectal lesions was performed safely and successfully in an outpatient setting, based on data from more than 600 patients.

The widespread adoption of endoscopic submucosal dissection (ESD) has been slow because of its relative complexity, compared with other procedures, wrote Viktor Tidehag, MD, of Danderyd Hospital, Stockholm, and colleagues. The technique, first developed in Japan, is usually an inpatient procedure in Asian countries, the researchers said. However, “We have previously published a study of 156 ESD patients discharged after 2-4 hours of observation post ESD, providing a proof of concept that uncomplicated colorectal ESD can be safely performed as an outpatient procedure,” they wrote.

Colorectal cancer, medical anatomical illustration ChrisChrisW/iStock/Getty Images

In a study published in Gastrointestinal Endoscopy, the researchers reviewed data from a larger group of 660 consecutive colorectal ESD procedures at a single center between April 2014 and November 2020. Of these, 48 were planned admission and 612 were scheduled as outpatient procedures. All patients had lesions greater than 20 mm; the median size of the lesions was 38 mm, but the median lesion size was significantly smaller for outpatients, compared with inpatients (37 mm vs. 55 mm). The lesions included 323 (48.9%) in the proximal colon, 102 (15.5%) in the distal colon, and 235 (35.6%) in the rectum. The median procedure duration was 70 minutes, but was significantly shorter for outpatients, compared with inpatients (65 minutes vs. 121 minutes). The mean age of patients in the outpatient and inpatient groups was 68.7 years vs. 70.6 years.

Overall, en bloc resection was achieved in 620 (93.9%) cases, 30 were completed as piecemeal resections, and 10 were aborted and referred for surgical resection. A total of 33 of the scheduled outpatient procedures turned into unplanned inpatient procedures.

As for intraoperative adverse events, no significant differences in perforation rate occurred between inpatients and outpatients. Overall, perforation occurred in 38 cases (5.8%); 35 of these were treated with clip and 21 also were treated with antibiotics. A total of three patients required emergency surgery following perforations.

Within 30 days of the procedures, 46 patients (7.0%) sought medical attention for possible procedure-related concerns, the researchers said. “No correlation was found between 30-day complications and lesion location, resection speed, age, or perioperative perforation,” the researchers wrote in their discussion of the findings.

The study findings were limited by several factors including the retrospective, nonrandomized design from a single center, with no controls, as well as the potential for selection bias of healthy patients selected for outpatient procedures, and lack of data on comorbidities, the researchers noted. However, the results were strengthened by the inclusion of a large number of lesions in the proximal colon, they said.

Endoscopic treatment is associated with lower mortality and morbidity, as well as lower costs, compared with laparoscopic and open surgery, and ESD could have a significant effect on health economics if widely implemented, the researchers noted in their discussion. “Being able to perform ESD in an outpatient setting compared to an inpatient situation would further decrease treatment costs compared to resection surgery,” they said. However, “patients must be well informed about the anticipated postoperative course and potential complications that can arise,” particularly in relation to intraprocedural or delayed perforation, they concluded.

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