News

Pharma-Sponsored Comparison Studies Hold Clinical Value


 

EXPERT ANALYSIS FROM THE COASTAL DERMATOLOGY SYMPOSIUM

Methotrexate Vs. Azathioprine for Atopy

In the treatment of severe atopic dermatitis, methotrexate and azathioprine were found to be almost equal in efficacy (42% vs. 39%, respectively). Patients (52 completed the study) were randomized to receive 10-22.5 mg of methotrexate per week or 1.5-2.2 mg/kg per day for 12 weeks (J. Allergy Clin. Immunol. 2011;128:353-9). Outcome was assessed by blinded reviewers.

"I think that the adverse event profile of methotrexate in most people is much better, so I tend to disagree with the outcome of this study," said Dr. Fowler.

Dr. Fowler reported financial conflicts of interest with multiple pharmaceutical companies, including many of the products mentioned during his presentation.



Pages

Recommended Reading

Hospital Bloodstream Infections: Intra-Abdominal Sources Most Common
MDedge Internal Medicine
Metronidazole Equals Vancomycin in C. Diff. Diarrhea
MDedge Internal Medicine
Skin and Soft Tissue Infection Rates, Costs Rise
MDedge Internal Medicine
What's New With Flu? For Doctors, Vaccination by Example
MDedge Internal Medicine
Bedbug Insecticides More Harmful Than the Pest
MDedge Internal Medicine
Beware of Curtain! Pathogens Plentiful on Hospital Partitions
MDedge Internal Medicine
Infection, Not Vaccination, May Be Culprit in Post-H1N1 Narcolepsy
MDedge Internal Medicine
Consider Hepatitis C Infection in Some Arthritis Patients
MDedge Internal Medicine
Rule Helped Detect Asymptomatic C. difficile Carriers
MDedge Internal Medicine
Natural Disaster Sites Breed Serious Infections
MDedge Internal Medicine