For patients with a history of AERD, they do the desensitization in their CCU or ICU, and space out each incremental dose in the sequence by 2-3 hours, doing the protocol over 2 days. They modeled this approach on a 2003 report by Dr. Donald D. Stevenson of the Scripps Clinic, La Jolla, Calif. (Clin. Rev. Allergy Immunol. 2003;24:159-67).
None of the 14 coronary disease patients in the series from Lahey included patients with AERD. All 14 patients underwent successful desensitization, with 3 having a reaction during the process, in one case a respiratory reaction.
Dr. Saryan, Dr. Wedner, and Dr. Riester said that they had no disclosures.