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No Survival Benefit Seen for EVAR Over Open Surgery for Ruptured AAA

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Not a Clear-Cut Case


Dr. Manish Mehta

[The researchers’] experience indicates that, with expertise in both emergent endovascular aneurysm repair (EVAR) and OSR, the short-term mortality can be equally reduced in both groups, albeit the morbidity of ruptured EVAR is significantly lower. It would also appear that all 37 patients (100%) with ruptured EVAR and only 111 of 241 patients (46%) with ruptured OSR ... underwent propensity score–based analysis. ... I feel obliged to comment that their inability to include the remaining 54% of patients with ruptured OSR has resulted in a cumulative midterm Kaplan-Meier survival analysis that would strongly bias in favor of OSR.

Dr. Manish Mehta is a vascular surgeon with the Albany (N.Y.) Vascular Group. His remarks were part of an invited commentary (J. Vasc. Surg. 2012;56:620). Dr. Mehta did not disclose any potential conflicts of interest.


 

FROM THE JOURNAL OF VASCULAR SURGERY

The limitations the authors pointed out were those inherent to a retrospective study with a relatively small sample size. In addition, there might have been a selection bias on the choice of treatment rendered. Propensity score–based matching can only remove overt bias; unlike randomization, it cannot remove hidden biases.

"There is still equipoise on what the best treatment for ruptured AAA is. The data [in the literature] are conflicting, and many studies showing improved outcomes with REVAR employed it preferentially for patients with favorable anatomy and hemodynamic stability. Preferential REVAR should be deferred until results of prospective, randomized trials are available and predictive factors for its success are identified. Some patients may be harmed by indiscriminate insistence on REVAR," Dr. Cho and his colleagues concluded.

The authors reported that they had no conflicts of interest with regard to their paper.

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