News

Federal government releases updated viral hepatitis action plan

View on the News

The most important goal is increasing awareness of infection

"Perhaps the goal with the greatest potential impact relates to increasing awareness of HCV infection," said Dr. Sean Koppe. He noted that less than half of patients with HCV know they are infected, and patients who are unaware of their infections may not learn they have progressive liver disease until they develop symptoms of cirrhosis.

"From the HCV standpoint, I think the action plan is a step, albeit a step that should have been taken several years ago, given that we are currently in the midst of the tremendous burden of HCV cirrhosis and hepatocellular carcinoma," Dr. Koppe said.


Dr. Sean W. Koppe

With expanded health coverage under the Affordable Care Act, increasing awareness of HCV infection to more than 66% is achievable by 2020, he said. "I think that the CDC [Centers for Disease Control and Prevention] and U.S. Preventive Services Task Force recommendation to screen for HCV in those born between 1945 and 1965 will have a significant impact on increasing awareness of HCV infection. Primary care providers are generally well aware of USPSTF recommendations and are implementing these in their practices. We’ve already experienced an increase of newly diagnosed HCV patients in our hepatology clinics that have been diagnosed because of HCV screening by their primary care provider."

The advent of highly effective and tolerable interferon-free regimens for HCV may have some impact on the goals, said Dr. Koppe. But "in addition to increasing awareness of HCV, governmental agencies also need to ensure access to treatment," he said.

"With the recently approved sofosbuvir and its retail price of $1,000 per pill, we are experiencing some challenges with getting some patients access to this highly effective and expensive medication. Because of budget limitations at the VA [Department of Veteran Affairs], we must be highly selective in how we use this medication, and the Department of Veteran Affairs cannot currently afford to treat all of the hepatitis C patients under their care unless Congress increases its budget."

The hepatitis B goals also are relevant, Dr. Koppe said. "It seems one of the biggest barriers to preventing vertical transmission is identifying pregnant women with hepatitis B early enough in pregnancy to allow for antiviral treatment if they are significantly viremic," he said. "In these patients, the use of hepatitis B immunoglobulin and vaccination of the newborn is typically not adequate to prevent transmission."

Dr. Koppe is a gastroenterologist with the Northwestern University Feinberg School of Medicine and the Jesse Brown VA Medical Center, Chicago. His remarks were excerpted from an interview with Frontline Medical News.


 

The federal government on April 4 published a 3-year update of its viral hepatitis action plan that emphasizes the need to expand awareness of infection; improve surveillance, testing, and treatment; eliminate vaccine-preventable hepatitis; and reduce transmission of hepatitis C virus infection.

By 2020, the updated action plan calls for the United States to double the proportion of patients who know they have hepatitis B virus infection (from 33% to 66%); increase the percentage of patients who know they have HCV infection (from 45% to 66%); cut new HCV infections by 25%; and eliminate maternal-child HBV transmission.

Measures of progress include hepatitis B and C mortality and hepatitis B vaccination coverage among health care workers. The plan builds on recent strides in viral hepatitis prevention and treatment – including more widespread availability of safe, effective vaccines for hepatitis A and B and the development of highly effective direct-acting antivirals for chronic hepatitis C infection.

But despite these advances, 3.5-5.3 million Americans still have viral hepatitis, and most do not know they are infected. Sequelae of these infections cause 12,000-18,000 deaths annually – a higher death toll than that from HIV, according to the U.S. Department of Health & Human Services.

The agency authored the plan with input from the Department of Veterans Affairs, the Department of Justice’s Federal Bureau of Prisons, and the Department of Housing and Urban Development.

Recommended Reading

Chronic pancreatitis life expectancy dramatically decreased
MDedge Internal Medicine
Liver histology crucial at Wilson disease diagnosis
MDedge Internal Medicine
Small PNETs may still harbor malignant potential
MDedge Internal Medicine
Pediatric information added to label of hepatitis B antiviral entecavir
MDedge Internal Medicine
Patient selection can keep the lid on esophagectomy costs
MDedge Internal Medicine
FDA panel says blood test for colorectal cancer screening is safe, not effective
MDedge Internal Medicine
FDA panel unanimously supports Cologuard colorectal cancer test
MDedge Internal Medicine
Better survival with aspirin in HLA class 1 antigen-positive cancers only
MDedge Internal Medicine
Physician’s adenoma detection rate predicts patient’s cancer risk
MDedge Internal Medicine
Sacral nerve stimulation reduced irritable bowel symptoms
MDedge Internal Medicine