Key clinical point: Interictal plasma amylin levels are higher in patients with chronic migraine and may serve as a better diagnostic marker than calcitonin gene-related peptide (CGRP).
Major finding: Plasma amylin levels were higher in chronic migraine patients than in episodic migraine patients and healthy controls (both P less than. 0001). Diagnostic performance was better with plasma amylin than CGRP in differentiating chronic migraine from healthy controls in adults.
Study details: The data come from a prospective case-controlled study involving 191 patients with chronic migraine, 58 patients with episodic migraine, and 68 healthy controls.
Disclosures: This study was funded by the Spanish Research Network on Cerebrovascular Diseases, Center for Applied Medical Research, University of Navarra, and Spanish Ministry of Economy and Competitiveness. The authors declared no conflicts of interest.
Source: Irimia P et al. Cephalalgia. 2020 Dec 3. doi: 10.1177/0333102420977106.