Hippocampal sclerosis (HS) and TAR-DNA binding protein of 43kDa (TDP-43) impact underlying global cognitive impairment and probable Alzheimer disease (AD) in older subjects, according to a review of 636 autopsied subjects in the Religious Order Study and the Rush Memory and Aging Project.
Researchers measured HS, as defined as severe neuronal loss and gliosis in the hippocampal CA1 and/or subiculum, and evaluated the severity and distribution of TDP-43 and other age-related pathologies. They determined:
• HS is more common in subjects older than 90 years old than younger patients, 18% to 9.2%
• TDP-43 pathology commonly coexists with HS, 86%
• HS commonly coexists with AD and Lewy body pathology, however only TDP-43 increased the odds of HS, (odds ratio [OR], 2.63)
• After adjusting for age and age-related pathologies, HS cases had higher odds of dementia (OR, 3.71) and probably AD (OR, 3.75)
Citation: Nag S, Yu L, Capuano AW, et al. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol. 2015;77(6):942-952. doi: 10.1002/ana.24388.