Other patients present with progressive disease, but without evidence of active inflammatory disease, and are not taking any medication. These patients also can be encouraged to participate in a clinical trial if they are eligible. “It’s important to explain the status of the evidence, which basically does not justify putting them on a disease-modifying therapy,” said Dr. Bourdette. If, after a discussion with the neurologist, a patient decides to try a drug, the patient should use the safest medication available and understand that the treatment is off label, he concluded.
—Erik Greb