New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus without an obvious cause after initial investigations. It carries a high rate of complications and mortality, and affected individuals are most often treated for weeks in an intensive care unit because they require prolonged anesthesia with coma-inducing drugs to control their seizures. Nicholas Gaspard, MD, PhD, and colleagues have published a review of patients treated from 2008 to 2013 at 13 academic medical centers.