Along with their colleague Dr. Steven DeKosky, chair of the neurology department at the University of Pittsburgh, the researchers are currently using the technique in patients with dementia of unknown origin.
PET with PIB reveals differences in amyloid deposition between cognitively normal subjects (far left) and subjects with AD (far right). PET with PIB also reveals the range of amyloid accumulation in subjects with clinically mild cognitive impairment (center). Courtesy Dr. William E. Klunk, Ph.D. and Chester Mathis, Ph.D./University of Pittsburgh