Major Finding: A pediatric version of the NIH Stroke Scale demonstrated excellent interrater reliability in a prospective validation study.
Data Source: Pediatric neurologists at 15 North American medical centers tested the PedNIHSS by using it to examine 113 children with acute arterial ischemic stroke, with interrater reliability tested in 25 patients.
Disclosures: Dr. Ichord and one of her associates in the study are on the clinical event committee for the Berlin Heart Trial for pediatric ventricular assist devices.
LOS ANGELES – For the first time, a pediatric stroke severity scale has been validated in a prospective clinical trial.
The study in 15 North American medical centers showed excellent interrater reliability when neurologists used a pediatric version of the National Institutes of Health Stroke Scale for adults to examine children aged 2-18 years with acute arterial ischemic stroke.
The neurologists used the Pediatric NIH Stroke Scale (PedNIHSS) on 113 patients who were examined daily from admission to discharge, or day 7 of hospitalization.
Interrater reliability was tested in a subset of 25 patients who underwent simultaneous examinations by two pediatric neurologists. Characteristics of the subgroup were similar to those of the entire cohort, Dr. Rebecca N. Ichord reported at the conference.
The simultaneous raters' scores were identical in 60% of ratings and were within a 1-point difference in 84% of ratings (Stroke 2011;42:613-7).
Research into potential ways of preventing or treating childhood stroke has been stymied in the past by the lack of a validated and reliable pediatric stroke scale. The PedNIHSS provides a way to index the severity of a child's stroke, to make comparisons across treatment groups, and to get a baseline for predicting outcome, said Dr. Ichord, director of the pediatric stroke program at the Children's Hospital of Philadelphia.
Clinicians, too, have wanted such a scale. “I have been asked over and over again [for a pediatric stroke scale] by clinicians who want to have a method of describing the severity of a child's stroke,” Dr. Ichord said at the meeting, which was sponsored by the American Heart Association. “It helps them with clinical decision making. It helps them to prepare parents and counsel parents.”
Characteristics of the patients and the strokes in the study were similar to those reported in previous pediatric stroke cohort studies, which suggests the current findings are generalizable and the PedNIHSS should be applicable in other settings. Because all of the raters in the current study were pediatric neurologists or trainees, a separate study is needed to assess the PedNIHSS in the hands of other specialists, she said.
The pediatric version also found good interrater reliability for facial weakness, dysarthria, and ataxia, which was not seen with the adult stroke scale. The reasons for this difference are unclear.
The use of the pediatric scale is limited to 2-18 years because younger children have limited language abilities, which are needed for use of the PedNIHSS. Neonates and children younger than 2 years of age with acute ischemic stroke may require a scale with less emphasis on focal sensorimotor deficits, the investigators suggested.
A video interview with Dr. Ichord about the scale can be viewed by using the QR code, or by visiting www.clinicalneurologynews.com
The PedNIHSS helps clinicians with clinical decision making and helps them to prepare and counsel parents.
Source DR. ICHORD