The finding of increased levels of HDAC2 in the Alzheimer’s disease brain doesn’t necessarily indicate that it is the cause of cognitive decline, he said. "The AD brain is a mess. You’ve got increased and decreased levels of all sorts of things."
Dr. Moir also noted that there’s not a lot of genetics that point in the direction of HDAC2 for Alzheimer’s.
The research was partly supported by the Stanley Medical Research Institution, the National Institute on Drug Abuse, and the National Institute for Neurological Disorders and Stroke. The authors declared having no financial disclosures.