Resting-state functional imaging revealed static functional connectivity and dynamic functional connectivity differences between migraine and persistent post-traumatic headache for regions involved in pain processing, a new study found. The case-control study integrated the static functional connectivity and dynamic functional connectivity patterns of 59 a priori selected regions of interest involved in pain processing. Pairwise connectivity differences between migraine (n=33) and persistent post-traumatic headache (n=44) were determined and compared to healthy controls (n=36) with ANOVA and subsequent t-tests. Researchers found:
- Significant differences in static functional connectivity between migraine and persistent post-traumatic headache were found for 17 region pairs.
- Significant differences in dynamic functional connectivity between migraine and persistent post-traumatic headache were found for 10 region pairs.
- These differences in functional connectivity may be indicative of pathophysiology associated with migraine vs persistent post-traumatic headache.
Dumkrieger G, et al. Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: A resting-state magnetic resonance imaging study. [Published online ahead of print May 1, 2019]. Cephalalgia. doi: 10.1177/0333102419847728.