Higher serum high-density lipoprotein (HDL) is associated with lower levels of blood brain barrier (BBB) injury and decreased CD80+ and CD80+CD19+ cell extravasation into the cerebrospinal fluid (CSF), according to a study of 154 patients with MS who were receiving interferon beta-1a therapy following their first clinical demyelinating event. Researchers found:
• Higher levels of serum HDL cholesterol (HDL-C) and apolipoprotein A-1 were associated with lower CSF total protein level, CSF albumin level, albumin quotient, and CSF IgC level.
• HDL-C was also associated with CSF CD80+ amd with CSF CD80+CD19+ cell frequencies.
Citation: Fellows K, Uher T, Browne RW, et al. Protective associations of HDL with blood brain barrier injury in multiple sclerosis patients. [Published online ahead of print August 4, 2015]. J Lipid Res. doi: 10.1194/jlr.M060970.