Conference Coverage

Delaying surgery didn’t impact survival in early-stage cervical cancer


 

FROM SGO 2021

Delaying surgery for up to 3 months had no adverse impact on overall survival in early-stage cervical cancer in a retrospective study of more than 4,700 women in the National Cancer Database.

Dimitrios Nasioudis, MD, of University of Pennsylvania, oncologist

Dr. Dimitrios Nasioudis

The 5-year overall survival rate was 85.7% among women who had radical hysterectomy and lymphadenectomy within 4 weeks of diagnosis, 86.6% among those who had the same surgery 4-8 weeks after diagnosis, and 89.6% among those who had surgery 8-12 weeks after diagnosis (P = .12).

“For patients with clinical stage I cervical carcinoma undergoing radical hysterectomy, we found no evidence of a detrimental effect of waiting time (up to 12 weeks from diagnosis) on overall survival,” the study investigators reported in a poster at the Society of Gynecologic Oncology’s Virtual Annual Meeting on Women’s Cancer.

The investigators looked at the issue of surgical wait times because of surgery delays due to the COVID-19 pandemic, according to investigator Dimitrios Nasioudis, MD, of the University of Pennsylvania in Philadelphia.

“We wanted to see if there was a real impact in the survival of patients,” Dr. Nasioudis said in an interview. He added that “many times, there is a question of when to perform surgery,” especially when patients need medical optimization.

Dr. Nasioudis called the findings “reassuring” and said “waiting up to 3 or 4 months is reasonable.”

Still, the investigators plan to validate the results with more granular patient-level institutional data, he said. Given the limits of the database, there was no information on tumor relapse or cause of death and no central pathology review.

Study details

The study included 4,782 patients who underwent primary radical hysterectomy with lymphadenectomy. Patients had clinical stage I adenocarcinoma, squamous, or adenosquamous carcinoma of the cervix, with no history of another tumor or other cervical surgery.

The median time to surgery was 34 days across the study population. Patients were divided into three groups according to the timing of their surgery:

  • Group 1 included 1,823 (38.1%) patients who had surgery less than 4 weeks from diagnosis.
  • Group 2 included 2,207 (46.2%) patients who had surgery 4-8 weeks from diagnosis.
  • Group 3 included 752 (15.7%) patients who had surgery 8-12 weeks from diagnosis.

Patients in group 1 had a higher rate of positive lymph nodes, compared with patients in groups 2 and 3 (18.4%, 15.6%, and 14.7%, respectively; P = .014). Patients in group 1 also had a higher incidence of lymphovascular space invasion (42.1%, 38.1%, and 33%; P = .007) and a higher rate of positive surgical margins (6.3%, 5.2%, and 3.9%; P = .047).

Group 1 patients “had more aggressive features,” which could explain why they had surgery within a month, Dr. Nasioudis said.

Patients in groups 3 and 2 were more likely to have government insurance, compared with patients in group 1 (35.6%, 31.6%, and 24.6%, respectively P < .001). Group 3 patients were more likely than those in groups 2 and 1 to have comorbidities (14.2%, 11.6%, and 10.5%; P = .29).

However, there were no survival differences between groups in a multivariate analysis controlling for confounders, which included tumor size, histology and extension, status of lymph nodes, receipt of radiotherapy, patient age, insurance, race, and comorbidities. Furthermore, in a stratified analysis based on tumor extent, the timing of surgery had no impact on survival.

Dr. Nasioudis said he suspects access to care was an issue for some women, and there were likely delays for medical optimization.

Access to gynecologic oncology services at the University of Pennsylvania is “pretty easy,” he said, so delays are usually related to medical optimization, but that’s not always the case in underserved areas of the United States.

There was no funding for this study, and the investigators didn’t have any disclosures.

aotto@mdedge.com

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