The ISPD recommends that the following information be conveyed to the patient:
- The test identifies only Down syndrome, or only “about half of the fetal aneuploidy that would be identified through amniocentesis or CVS”.
- The test is not perfect; that is, it does not identify all cases of fetal Down syndrome.
- Because false-positive results are possible, women who test positive still need the result confirmed by amniocentesis or CVS.
- If a woman tests positive for Down syndrome on the MPS test, the waiting period for the results of confirmatory testing may be “highly stressful”.
- The MPS test may not be informative in all cases.
- Women who have an elevated risk of having a child with a “prenatally diagnosable disorder with Mendelian pattern of inheritance, microdeletion syndrome, or some other conditions” still need to undergo amniocentesis or CVS.3
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