ATLANTA — Recent efforts to broaden influenza immunization among children have kept the thimerosal/autism issue on the front burner for the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
The link was evident at the ACIP's winter meeting, where plans were discussed to expand the recommended age range to receive annual flu shots from the current 6 months-5 years to children up through age 18. This could happen as soon as the 2008–2009 influenza season (see story above).
Most routine childhood vaccines no longer contain thimerosal, but influenza vaccine remains a notable exception: Only the intranasal vaccine and one brand of injectable influenza vaccine are currently thimerosal free, while the rest still contain small amounts. All of the influenza vaccine manufacturers are working toward producing preservative-free vaccine, and greater capacity is expected over the next 3–5 years, Dr. Anthony Fiore of the CDC's National Center for Influenza and Respiratory Diseases told the committee.
In the meantime, activist groups claiming a link between thimerosal and the documented rise in the number of children being diagnosed with autism spectrum disorders have kept the issue in the news and on the ACIP's agenda. The committee's 2007–2008 influenza statement will specifically state that “no scientifically conclusive evidence has demonstrated harm from exposure to thimerosal preservative-containing vaccine” and that individuals receiving influenza vaccine may be given “any age- and risk-factor appropriate vaccine preparation, depending on availability.”
At the committee's request, Dr. Jay M. Lieberman presented a summary of the evidence regarding autism and thimerosal, an organic preservative containing 50% ethylmercury that once was commonly used in multidose vaccine containers to prevent microbial growth.
In 1999, the American Academy of Pediatrics and the U.S. Food and Drug Administration urged manufacturers to remove thimerosal from vaccines as quickly as possible, because of the discovery that young children receiving multiple immunizations could exceed the total mercury exposure level recommended by the Environmental Protection Agency, said Dr. Lieberman, chief of pediatric infectious diseases at Miller Children's Hospital, Long Beach, Calif.
In a subsequent statement, the CDC noted that the goal of removing thimerosal from vaccines was “established as a precautionary measure to maintain the public's trust in immunization,” and that “there was no evidence of any harm caused by the low levels in vaccines, but removal would make vaccines safer” (MMWR 2000;49:622).
The relevant data come primarily from cohort and ecological studies. In a population-based cohort study of all 467,450 children born in Denmark during 1990–1996, the risk of autism and autism spectrum disorders did not differ significantly between those vaccinated with thimerosal-containing vaccines and those who received the thimerosal-free versions, and there was no evidence for a dose-response association (JAMA 2003;290:1763–6).
Preliminary data from a 1999 “screening study” of more than 140,000 U.S. children in the Vaccine Safety Datalink Project did suggest an association between thimerosal exposure and “any neurodevelopmental disorder”—but not autism—at 3 months. Those initial results have been widely quoted by activists as evidence for the dangers of thimerosal. However, the study showed no clear association between infant exposure to thimerosal and specific neurodevelopmental disorders. After various methodological errors and issues were resolved, the final published version of the report was less conclusive (Pediatrics 2003;11:1039–48).
“It's important to note that this study was undertaken to identify outcomes that warranted additional study. The authors recognized that there were likely to be other important factors that couldn't be addressed in this study design,” Dr. Lieberman said.
While the increase in the incidence and prevalence of autism spectrum disorders in the United States during the 1980s and 1990s paralleled exposure to thimerosal-containing vaccines, the story is different in Denmark and Sweden, where rates of autism continued to rise even after thimerosal was removed from vaccines (Am. J. Prev. Med. 2003;25:101–6 and Pediatrics 2003;112:604–6). Similarly, emerging data in the United States suggest that autism rates have not decreased with the removal of thimerosal from routine childhood vaccines, Dr. Lieberman noted.
In 2004, a data review by the Institute of Medicine determined that “the evidence favors rejection of a causal relationship” between thimerosal-containing vaccines and autism.
But judging by some of the public comments at the meeting, not everyone is convinced. Lyn Redwood, R.N., president and cofounder of a nonprofit organization called Sensible Action for Ending Mercury-Induced Neurological Disorders (SafeMinds), urged the ACIP to stop recommending any vaccines that contain thimerosal. She read a list of titles from published scientific articles, such as “Thimerosal Neurotoxicity Is Associated With Glutathione Depletion: Protection With Glutathione Precursors” (Neurotoxicology 2005;26:1–8).