Clinical Edge Journal Scan

Hypogonadism is a key risk factor for fractures in glucocorticoid-induced osteoporosis


 

Key clinical point: Hypogonadism is a major risk factor for the development of fractures in men and women treated with glucocorticoid (GC).

Major finding: Major risk factors for vertebral fracture were hypogonadism (odds ratio [OR], 12.38; P = .01) and receiving GC boluses (OR 3.45; P = .01) and that for friability fracture were hypogonadism (OR, 7.03; P = .01) and a FRAX index greater than 20 (OR, 7.08; P = .02).

Study details: A cross-sectional study of 127 adults receiving chronic GC treatment for a rheumatological autoimmune disease.

Disclosures: This study was funded in part by the Societat Catalana de Reumatologia. The authors declared no conflicts of interest.

Citation: Florez H et al. RMD Open. 2020 Sep 10. doi: 10.1136/rmdopen-2020-001355 .

Recommended Reading

Treatment sequence with romosozumab influences osteoporosis outcomes
MDedge Rheumatology
Osteoporosis underdiagnosed in older men with fracture
MDedge Rheumatology
Denosumab favored over alendronate for BMD protection in glucocorticoid-induced osteoporosis
MDedge Rheumatology
Age-related macular degeneration tied to fracture risk in patients with osteoporosis
MDedge Rheumatology
Serum vitamin K1 inversely related to fracture risk in postmenopausal osteoporosis
MDedge Rheumatology
MetS linked to increased risk for low BMD in women with suspected osteoporosis
MDedge Rheumatology
Lumbar spine BMD inversely linked to coronary artery calcification in patients with osteoporosis
MDedge Rheumatology
Osteoporosis: Minodronate shows better clinical efficacy than comparators in meta-analysis
MDedge Rheumatology
High-dose ICS tied to osteoporosis and fracture risk in COPD
MDedge Rheumatology
Forearm BMD and fracture incidence in postmenopausal women with osteoporosis
MDedge Rheumatology