Aspirin Prophylaxis for Thromboembolic Disease After Total Joint Arthroplasty

The most appropriate prophylactic regimen for thromboembolic disease has not been determined. There appear to be several good alternatives, all of which yield similar results as determined by the incidence of symptomatic pulmonary embolism, but all are associated with various bleeding-related risks. Results from past research of almost 3500 total knee arthroplasties demonstrated a low risk for pulmonary emboli (0.1%) and a reduced risk for postoperative bleeding with use of aspirin and foot pumps as prophylaxis against thromboembolic disease. We continue to remain comfortable recommending this regimen for our patients.