Article
How does gender-affirming hormone therapy affect QOL in transgender patients?
EVIDENCE-BASED ANSWER: There are modest effects on depression but not anxiety. Gender-affirming hormone therapy (GAHT) is associated with modest...
Article
Is event-driven PrEP dosing for HIV as effective as daily dosing?
Probably, although there are no head-to-head trials comparing the 2 dosing regimens. Event-driven pre-exposure prophylaxis (PrEP) dosing...
Article
Is metformin effective for reducing weight in obese or overweight adolescents?
EVIDENCE-BASED ANSWER: Yes, to some degree—but it is of uncertain clinical significance. Over a period of 6 months, metformin modestly reduced...
Article
Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
EVIDENCE-BASED ANSWER: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary...
Article
Does vitamin D supplementation reduce asthma exacerbations?
EVIDENCE-BASED ANSWER: Yes, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma...
Article
Does screening by primary care providers effectively detect melanoma and other skin cancers?
EVIDENCE-BASED ANSWER: Possibly. No trials have directly assessed detection of melanoma and other skin cancers by primary care providers.
Article
Does using e-cigarettes increase cigarette smoking in adolescents?
EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...
Opinion
Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?
EVIDENCE-BASED ANSWER: Probably not, based on the balance of evidence. While low-quality evidence may suggest potential benefit,...
Article
Does amniotomy shorten spontaneous labor or improve outcomes?
EVIDENCE-BASED ANSWER: No. Amniotomy neither shortens spontaneous labor nor improves any of the following outcomes: length of first stage of labor...
Article
What’s the best VTE treatment for patients with cancer?
EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...
Article
What’s the best secondary treatment for patients who fail initial triple therapy for H pylori?
EVIDENCE-BASED ANSWER: Treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple therapy with either...