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Abatacept response in seropositive RA may be linked to HLA gene
MADRID – Patients who had the shared epitope in HLA-DRB1 had better responses to abatacept than adalimumab in the phase 4 Early AMPLE trial.
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Recognize and assess RA fatigue routinely, rheumatology experts urge
MADRID – Fatigue is a common and persistent problem affecting up to 80% of patients with rheumatoid arthritis and is severe in half of cases.
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Mechanism does not matter for second-line biologic choice in JIA
MADRID – There was no difference in effectiveness outcomes or drug survival when switching to a second biologic with an alternate mechanism of...
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Tildrakizumab shows positive effects in active psoriatic arthritis
MADRID – Already approved as a treatment for chronic plaque psoriasis, tildrakizumab (Ilumya) may also be beneficial in psoriatic arthritis,...
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Repeated ANA testing after negative result of little diagnostic value
MADRID – In a retrospective analysis, 79% of repeated antinuclear antibody tests for ANA-associated rheumatologic conditions remained the same....
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RNase drug shows promise for Sjögren’s fatigue
MADRID – RSLV-132 improved fatigue symptoms in patients with primary Sjögren’s syndrome in the phase 2, randomized, proof-of-concept RESOLVE study...
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Quality standards aim to improve worldwide spondyloarthritis care
MADRID – The Assessment of SpondyloArthritis international Society (ASAS) has developed nine new quality standards to improve the management of...
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Genetic variant could dictate rituximab response in lupus
MADRID – Genetic polymorphism in the Fc gamma receptor could be the reason why some patients with systemic lupus erythematosus do not respond to...
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Tanezumab improves osteoarthritis pain, function in phase 3 trial
MADRID – Trial showed strong differences in response to active treatment versus placebo despite being tested in “a difficult-to-treat population...
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Tocilizumab preserves lung function in systemic sclerosis
MADRID – The results of the focuSSced phase 3 study showed a significantly lower proportion of tocilizumab- than placebo-treated patients...
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Refractory RA responds to vagus nerve stimulation
MADRID – Pilot trial of a vagus nerve stimulator device shows relative safety and signs of efficacy over 12 weeks.
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Systemic sclerosis gastrointestinal symptoms helped by gut microbiota transplant
MADRID – Transplanting human intestinal microbiota into adult patients with limited systemic sclerosis improved gastrointestinal symptoms.
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Antibody hierarchy may drive development of SLE vs. antiphospholipid syndrome
MADRID – Specific antiphospholipid antibodies have differing influences on the manifestations of two important autoimmune diseases.
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Treat-to-target slowly emerging in axial spondyloarthritis
MADRID – While randomized trial data are awaited, observational evidence and expert opinion support the strategy in axial spondyloarthritis.
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Rituximab serious infection risk predicted by immunoglobulin levels
Retrospective study findings suggest measuring immunoglobulin levels at baseline and before each rituximab cycle to identify patients at risk of...