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Newly identified genetic changes contribute to transformation of follicular lymphoma
The case of a 36-year-old man whose low-grade follicular lymphoma transformed to B-ALL/LBL about 1 year after diagnosis sheds lights on the...
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Dupilumab could be treatment option for chronic keloids
Interleukin-4 receptors, directly targeted by dupilumab, were highly up-regulated in keloid lesions, compared with controls.
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Simple prevention strategies can lessen postoperative delirium after orthopedic surgery
A new study has found that
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Regular use of disinfectants at work associated with increased risk of COPD
Clinicians should look for sources of exposure to cleaning products and disinfectants in addition to other occupational exposures in patients with...
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Omalizumab proves effective for severe pediatric atopic dermatitis
Treatment with omalizumab for 24 weeks reduced severity and improved quality of life in pediatric patients with severe atopic dermatitis.
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Free HIV self-tests for at-risk groups can increase awareness, testing frequency
“HIV prevention programs might consider adding an HIV self-testing mail distribution component to their portfolio,” the investigators wrote.
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Vitamin D, omega-3 fatty acids do not preserve kidney function in type 2 diabetes
After 5 years of follow-up, the supplements showed no significant difference in change in eGFR, compared with placebo.
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Though metastatic breast cancer survival is improving, rates vary by region
A lag in survival improvement across different regions suggests that some groups and regions may benefit unequally from treatment advances as well...
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Two regenerative techniques prove comparable for repairing knee cartilage
Autologous matrix-induced chondrogenesis could be considered an equal alternative to techniques based on chondrocyte transplantation for treatment...
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Measles causes B-cell changes, leading to ‘immune amnesia’
This leads to an increase of secondary infections after a bout of measles.
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Triple-drug therapy proves effective in CF patients with most common mutation
Elexacaftor-tezacaftor-ivacaftor can modulate a single Phe508del allele in people with cystic fibrosis.
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TNF level–based dosing of infliximab does not increase RA remission rate
“The results did not support our initial hypothesis that deep remission and subsequent sustained discontinuation of infliximab can be achieved by...
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Demeaning patient behavior takes emotional toll on physicians
Deciding how or whether to respond was often dictated by the level of support from colleagues, a professional responsibility to peers.
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Beta-blocker treatment did not reduce exacerbation risk in COPD
The use of metoprolol did not significantly reduce the median time to first exacerbation in COPD, compared with placebo.
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DNA methylation changes: An early biomarker for methotrexate response?
Several differentially methylated positions at 4 weeks were associated with good treatment response at 6 months.